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	Provedor de dados BJMBR (4) Autor Alves-Do-Prado,W. (4) Ambiel,C.R. (1) Bazotte,R.B. (1) Cruciol-Souza,J.M. (1) Curi,R. (1) Lopes,G. (1) Queiroz,R.N. (1) Ramos,E.R.P. (1) Mais... Palavra-chave Skeletal muscle (4) Nitric oxide (3) Tetanic fade (3) Atropine (2) CGMP (1) Carnitine (1) K+ channel (1) L-arginine (1) Methylene blue (1) Muscarinic receptors (1) Wedensky inhibition (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Info:eu-repo/semantics/other (1) Ano 2003 (2) 1999 (1) 1998 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última 4-Aminopyridine inhibits the neuromuscular effects of nitric oxide and 8-Br-cGMP BJMBR Queiroz,R.N.; Ramos,E.R.P.; Alves-Do-Prado,W.. The effects induced by nitric oxide (NO) in different tissues depend on direct and/or indirect interactions with K+ channels. The indirect interaction of NO is produced by activation of guanylyl cyclase which increases the intracellular cGMP. Since NO, cGMP and 4-aminopyridine alone induce tetanic fade and increase amplitude of muscular contractions in isolated rat neuromuscular preparations, the present study was undertaken to determine whether or not the neuromuscular effects of NO and 8-Br-cGMP can be modified by 4-aminopyridine. Using the phrenic nerve and diaphragm muscle isolated from male Wistar rats (200-250 g), we observed that L-arginine (4.7 mM) and 8-Br-cGMP (18 µM), in contrast to D-arginine, induced an increase in the amplitude of muscle... Tipo: Info:eu-repo/semantics/other Palavras-chave: L-arginine; Nitric oxide; CGMP; Skeletal muscle; Tetanic fade; K+ channel. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000700016 Atropine and ODQ antagonize tetanic fade induced by L-arginine in cats BJMBR Cruciol-Souza,J.M.; Alves-Do-Prado,W.. Although it has been demonstrated that nitric oxide (NO) released from sodium nitrite induces tetanic fade in the cat neuromuscular preparations, the effect of L-arginine on tetanic fade and its origin induced by NO have not been studied in these preparations. Furthermore, atropine reduces tetanic fade induced by several cholinergic and anticholinergic drugs in these preparations, whose mechanism is suggested to be mediated by the interaction of acetylcholine with inhibitory presynaptic muscarinic receptors. The present study was conducted in cats to determine the effects of L-arginine alone or after pretreatment with atropine or 1H-[1,2,4]oxadiazole [4,3-a]quinoxalin-1-one (ODQ) on neuromuscular preparations indirectly stimulated at high frequency. Drugs... Tipo: Info:eu-repo/semantics/article Palavras-chave: Atropine; Tetanic fade; Skeletal muscle; Nitric oxide; Muscarinic receptors. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001000015 L- and DL-carnitine induce tetanic fade in rat neuromuscular preparation BJMBR Lopes,G.; Bazotte,R.B.; Curi,R.; Alves-Do-Prado,W.. Carnitine, a structurally choline-like metabolite, has been used to increase athletic performance, although its effects on neuromuscular transmission have not been investigated. It is present in skeletal muscle and its plasma levels are about 30 to 90 µM. Using rat phrenic nerve diaphragm preparations indirectly and directly stimulated with high rate pulses, D-carnitine (30 and 60 µM), L-carnitine (60 µM) and DL-carnitine (60 µM) were shown to induce tetanic fade (D-carnitine = 19.7 ± 3.1%, N = 6; L-carnitine = 16.6 ± 2.4%, N = 6; DL-carnitine = 14.9 ± 2.1%, N = 6) without any reduction of maximal tetanic tension. D-carnitine induced tetanic fade in neuromuscular preparations previously paralyzed with d-tubocurarine and directly stimulated. The effect was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Carnitine; Skeletal muscle; Tetanic fade; Atropine. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900017 Reversal by methylene blue of tetanic fade induced in cats by nitric oxide BJMBR Ambiel,C.R.; Alves-Do-Prado,W.. Previous data from our laboratory have indicated that nitric oxide (NO) acting at the presynaptic level increases the amplitude of muscular contraction (AMC) of the phrenic-diaphragm preparations isolated from indirectly stimulated rats, but, by acting at the postsynaptic level, it reduces the AMC when the preparations are directly stimulated. In the present study we investigated the effects induced by NO when tetanic frequencies of stimulation were applied to in vivo preparations (sciatic nerve-anterior tibial muscle of the cat). Intra-arterial injection of NO (0.75-1.5 mg/kg) induced a dose-dependent increase in the Wedensky inhibition produced by high frequencies of stimulation applied to the motor nerve. Intra-arterial administration of 7.2 µg/kg... Tipo: Info:eu-repo/semantics/article Palavras-chave: Wedensky inhibition; Nitric oxide; Methylene blue; Skeletal muscle. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000300013 Registros recuperados: 4 Primeira ... 1 ... Última

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